NIPAL3

Across TCGA pan-cancer cohorts, NIPAL3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NIPAL3 data layer compared with 27 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NIPAL3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NIPAL3 expression acts as an unfavorable survival marker.

ACC, PRAD, and UCEC are the cancer types where NIPAL3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.256	0.809	<.001	36	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	III,IV	0.168	0.692	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NIPAL3–ACC (OS)

Open the ACC breakdown →