NIPAL3

Across TCGA patient cohorts, NIPAL3 mutation is significantly associated with the RNA expression of many other genes, with 1,076 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPAL3-associated genes across cancer lineages are RNU6-1305P, RNU6-601P, and LETM1. Each is linked with NIPAL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NIPAL3-to-partner and partner-to-NIPAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1305P grouped by NIPAL3-low versus NIPAL3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL3→partner) and Y-score (partner→NIPAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1305P →	+0.548	+5.912	<.001	.002	3	3
CESC	RNU6-601P →	+0.228	+4.757	<.001	.004	3	2
UCEC	LETM1 →	+0.440	+2.721	<.001	.003	3	2
UCEC	MRM3 →	+0.403	+2.329	.001	.003	3	2
UCEC	ATPAF2 →	+0.440	+2.860	<.001	.001	3	2
UCEC	WDR62 →	+0.471	+1.858	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,076 associations by consensus.

RNU6-1305P by NIPAL3 expression — HNSC

Explore this box plot interactively →