NIPAL3

Across TCGA patient cohorts, NIPAL3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPAL3-associated genes across cancer lineages are TFRC, ASNS, and Caspase-7-cleavedD198. Each is linked with NIPAL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPAL3-to-partner and partner-to-NIPAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by NIPAL3-low versus NIPAL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL3→partner) and Y-score (partner→NIPAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.608	+2.321	.005	.006	3	2
UCEC	ASNS →	+0.382	+2.321	.010	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+1.107	+2.584	<.001	.010	3	2
UCEC	4E-BP1 →	+0.370	+2.199	<.001	.033	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.807	.034	.027	3	1
UCEC	ERK2 →	+0.180	+2.321	.024	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

TFRC by NIPAL3 expression — UCEC

Explore this box plot interactively →