NIPAL3

Across TCGA cell cohorts, NIPAL3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NIPAL3-associated genes across cancer lineages are GML, GFRA4, and TSHB. Each is linked with NIPAL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPAL3-to-partner and partner-to-NIPAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by NIPAL3-low versus NIPAL3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL3→partner) and Y-score (partner→NIPAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.080	+4.152	<.001	.009	3	1
BLOOD_Leukemia	GFRA4 →	+0.295	+4.409	.001	.005	3	1
BLOOD_Leukemia	TSHB →	+0.120	+4.276	.005	.007	3	1
BLOOD_Leukemia	AWAT2 →	+0.010	+4.705	.004	.003	3	1
BLOOD_Leukemia	NKX2-6 →	+0.489	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	OR1G1 →	+0.083	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GML by NIPAL3 expression — BLOOD_Leukemia

Explore this box plot interactively →