NIPAL2

Across TCGA patient cohorts, NIPAL2 mutation is significantly associated with the RNA expression of many other genes, with 1,432 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPAL2-associated genes across cancer lineages are MIR1183, RNA5SP88, and TCP11X1. Each is linked with NIPAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPAL2-to-partner and partner-to-NIPAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1183 grouped by NIPAL2-low versus NIPAL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL2→partner) and Y-score (partner→NIPAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR1183 →	+0.467	+4.680	<.001	.007	3	2
UCEC	RNA5SP88 →	+0.408	+2.771	<.001	.003	3	2
LUSC	TCP11X1 →	+0.064	+5.404	<.001	.005	3	2
LUSC	FAM230F →	+0.086	+6.438	<.001	.001	3	2
SKCM	OR5D17P →	+0.054	+4.867	<.001	.005	3	1
SKCM	RNY1P1 →	+0.314	+4.970	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,432 associations by consensus.

MIR1183 by NIPAL2 expression — SKCM

Explore this box plot interactively →