NIPAL2

Across TCGA patient cohorts, NIPAL2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPAL2-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1173. Each is linked with NIPAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPAL2-to-partner and partner-to-NIPAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NIPAL2-low versus NIPAL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL2→partner) and Y-score (partner→NIPAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.103	-2.973	.023	.035	3	1
UCEC	eEF2 →	+0.486	+3.321	.002	.010	3	1
UCEC	EGFR_pY1173 →	+0.086	+2.026	.016	.018	3	1
UCEC	eIF4G →	+0.326	+3.169	.019	.019	3	1
UCEC	FASN →	+0.537	+2.700	.002	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.150	-2.312	.007	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

14-3-3_beta by NIPAL2 expression — UCEC

Explore this box plot interactively →