NIPAL2

Across TCGA cell cohorts, NIPAL2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NIPAL2-associated genes across cancer lineages are CRISP1, DAZ4, and OR6F1. Each is linked with NIPAL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPAL2-to-partner and partner-to-NIPAL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRISP1 grouped by NIPAL2-low versus NIPAL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL2→partner) and Y-score (partner→NIPAL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRISP1 →	+0.019	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DAZ4 →	+0.326	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	OR6F1 →	+0.186	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	TEX26 →	+0.021	+4.867	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CRISP1 by NIPAL2 expression — LARGE_INTESTINE

Explore this box plot interactively →