NIPAL1

Across TCGA patient cohorts, NIPAL1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPAL1-associated genes across cancer lineages are JNK_pT183_Y185, PDCD4, and c-Kit. Each is linked with NIPAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPAL1-to-partner and partner-to-NIPAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by NIPAL1-low versus NIPAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL1→partner) and Y-score (partner→NIPAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.202	-2.986	.038	.037	3	1
UCEC	PDCD4 →	-0.637	-3.000	.019	.037	1	2
SKCM	c-Kit →	-0.839	-3.000	.025	.036	2	1
UCEC	ATM →	-0.661	-3.000	.011	.037	1	1
SKCM	AR →	-0.197	-3.000	.026	.036	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

JNK_pT183_Y185 by NIPAL1 expression — UCEC

Explore this box plot interactively →