NIPAL1

Across TCGA cell cohorts, NIPAL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,432 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NIPAL1-associated GO terms across cancer lineages are Negative regulation of actin filament bundle assembly, Regulation of ventricular cardiac muscle cell action potential, and Rho protein signal transduction. Each is linked with NIPAL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both NIPAL1-to-partner and partner-to-NIPAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin filament bundle assembly grouped by NIPAL1-low versus NIPAL1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL1→partner) and Y-score (partner→NIPAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of actin filament bundle assembly →	+0.124	+1.517	<.001	<.001	3	13
BREAST	Regulation of ventricular cardiac muscle cell action potential →	+0.184	+1.238	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Rho protein signal transduction →	+0.097	+1.207	.003	<.001	2	12
OVARY	Negative regulation of stress fiber assembly →	+0.129	+1.552	<.001	<.001	3	11
PANCREAS	Protein localization to cell-cell junction →	+0.167	+1.710	<.001	<.001	3	9
BREAST	Bundle of His cell to Purkinje myocyte communication →	+0.400	+1.156	.009	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,432 associations by consensus.

Negative regulation of actin filament bundle assembly by NIPAL1 expression — OVARY

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