NIPAL1

Across TCGA cell cohorts, NIPAL1 mutation is significantly associated with the drug of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NIPAL1-associated genes across cancer lineages are GW-2580, Masitinib, and XMD13-2. Each is linked with NIPAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPAL1-to-partner and partner-to-NIPAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GW-2580 grouped by NIPAL1-low versus NIPAL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL1→partner) and Y-score (partner→NIPAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GW-2580 →	+0.415	+2.786	<.001	.037	3	1
LARGE_INTESTINE	Masitinib →	+0.435	+2.652	.043	.045	3	1
LARGE_INTESTINE	XMD13-2 →	+0.559	+2.652	.008	.045	3	1
LARGE_INTESTINE	ETP-45835 →	+0.280	+2.652	.019	.045	3	1
LARGE_INTESTINE	Staurosporine →	+0.520	+2.646	.026	.047	2	1
LARGE_INTESTINE	Palbociclib →	+0.589	+2.646	.015	.047	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

GW-2580 by NIPAL1 expression — LARGE_INTESTINE

Explore this box plot interactively →