NIPA2

Across TCGA patient cohorts, NIPA2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPA2-associated genes across cancer lineages are ERK2, MSH6, and p62 Lck ligand. Each is linked with NIPA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPA2-to-partner and partner-to-NIPA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NIPA2-low versus NIPA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPA2→partner) and Y-score (partner→NIPA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.181	+3.169	.036	.019	3	1
UCEC	MSH6 →	-0.541	-2.311	<.001	.034	3	1
UCEC	p62 Lck ligand →	+0.337	+2.700	.021	.006	3	1
UCEC	AMPK_pT172 →	+0.506	+2.013	.006	.018	3	1
UCEC	Annexin-1 →	+0.930	+3.604	<.001	.001	3	1
UCEC	Rictor_pT1135 →	-0.112	-2.321	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ERK2 by NIPA2 expression — UCEC

Explore this box plot interactively →