Across TCGA pan-cancer cohorts, NIP7P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NIP7P1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NIP7P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NIP7P1 is over-expressed in tumor.
HNSC and KIRP are the cancer types where NIP7P1 tumor–normal differential expression is most reproducible.