NIP7

Across TCGA patient cohorts, NIP7 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIP7-associated genes across cancer lineages are EGFR_pY1068, AR, and INPP4B. Each is linked with NIP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIP7-to-partner and partner-to-NIP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NIP7-low versus NIP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIP7→partner) and Y-score (partner→NIP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.371	-3.000	.007	.036	3	1
UCEC	AR →	-0.501	-3.169	.014	.020	3	1
UCEC	INPP4B →	-0.591	-3.169	<.001	.019	2	1
UCEC	p70-S6K_pT389 →	-0.230	-3.169	.027	.020	2	1
UCEC	Rab25 →	-0.435	-3.169	.016	.020	2	1
UCEC	Smad3 →	+0.187	+3.169	.024	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by NIP7 expression — UCEC

Explore this box plot interactively →