NINJ2

Across TCGA patient cohorts, NINJ2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NINJ2-associated genes across cancer lineages are PEA-15_pS116, S6, and MEK1. Each is linked with NINJ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NINJ2-to-partner and partner-to-NINJ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by NINJ2-low versus NINJ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NINJ2→partner) and Y-score (partner→NINJ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.400	+3.169	.037	.020	3	1
UCEC	S6 →	-0.304	-3.169	.038	.020	3	1
UCEC	MEK1 →	+0.641	+3.169	.001	.020	2	1
UCEC	Di-Ras3 →	-0.166	-3.169	.042	.020	2	1
UCEC	ATM →	-0.919	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PEA-15_pS116 by NINJ2 expression — UCEC

Explore this box plot interactively →