NINJ1

Across TCGA pan-cancer cohorts, NINJ1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NINJ1 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher NINJ1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NINJ1 expression acts as an unfavorable survival marker, although some lineages such as CESC and BRCA show a favorable association.

CESC, BRCA, and UCS are the cancer types where NINJ1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	IV	0.729	0.292	.001	96	view →
BRCA	OS	Tertile	II,III,IV	0.981	0.935	<.001	78	view →
UCS	OS	Median	IV	0.302	0.817	.002	66	view →
KICH	DFS	Median	III,IV	0.308	0.942	.001	57	view →
THCA	OS	Median	III,IV	0.988	0.740	.003	51	view →
KIRP	OS	Median	III,IV	0.815	0.145	<.001	48	view →
UCEC	DFS	Quartile	III,IV	0.901	0.682	.003	42	view →
LAML	DFS	Median	All	0.254	0.498	.001	34	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	30	view →
GBM	OS	Quartile	All	0.297	0.510	.002	28	view →
LIHC	OS	Quartile	All	0.692	0.835	.008	25	view →
MESO	OS	Median	All	0.485	0.298	.004	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NINJ1–CESC (DFS)

Open the CESC breakdown →