NIFKP8

Across TCGA pan-cancer cohorts, NIFKP8 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of NIFKP8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where NIFKP8 RNA is repressed in tumor relative to normal tissue. In most cancer types NIFKP8 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, BRCA, and LUSC are the cancer types where NIFKP8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NIFKP8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.265	<.001	6	view →
BRCA	Female	II,III,IV	+0.052	<.001	6	view →
LUSC	All	II,III,IV	−0.248	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

NIFKP8–LUAD

Open the LUAD breakdown →