NIFKP4

Across TCGA pan-cancer cohorts, NIFKP4 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated NIFKP4 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher NIFKP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NIFKP4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LAML show a favorable association.

MESO, KIRP, and LUSC are the cancer types where NIFKP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	IV	0.137	0.669	<.001	111	view →
KIRP	OS	Tertile	All	0.818	0.973	<.001	81	view →
LUSC	OS	Tertile	III,IV	0.346	0.643	.001	49	view →
DLBC	DFS	Tertile	IV	0.120	0.683	.001	36	view →
ESCA	OS	Median	All	0.418	1.000	.005	36	view →
BRCA	DFS	Tertile	II,III,IV	0.970	0.935	.039	24	view →
SKCM	DFS	Tertile	IV	0.134	0.589	.031	18	view →
KIRC	DFS	Median	II,III,IV	0.353	0.575	.020	15	view →
ACC	OS	Tertile	II,III,IV	0.650	0.884	.026	12	view →
LAML	DFS	Median	All	0.469	0.311	.047	10	view →
COAD	DFS	Tertile	All	0.692	0.797	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

NIFKP4–MESO (OS)

Open the MESO breakdown →