Across TCGA patient cohorts, NIF3L1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIF3L1-associated genes across cancer lineages are EGFR_pY1068, Fibronectin, and Heregulin. Each is linked with NIF3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIF3L1-to-partner and partner-to-NIF3L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIF3L1→partner) and Y-score (partner→NIF3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.211	-2.000	.032	.010	3	1
UCEC	Fibronectin →	-0.284	-1.990	.028	.030	3	1
UCEC	Heregulin →	-0.153	-2.000	.001	.030	3	1
UCEC	IRS1 →	-0.226	-3.321	.005	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.182	-2.459	.005	.019	3	1
UCEC	JNK2 →	+0.259	+3.611	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

NIF3L1 survival (RNA) · tumor vs normal (RNA) · all NIF3L1 data types