NID2

Across TCGA patient cohorts, NID2 mutation is significantly associated with the RNA expression of many other genes, with 5,244 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NID2-associated genes across cancer lineages are GUCA1B, OTX1, and EIF2B2. Each is linked with NID2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NID2-to-partner and partner-to-NID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1B grouped by NID2-low versus NID2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NID2→partner) and Y-score (partner→NID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUCA1B →	+0.365	+1.712	<.001	<.001	3	4
LUAD	OTX1 →	+0.509	+2.330	.007	.003	3	4
UCEC	EIF2B2 →	+0.273	+1.758	<.001	.001	3	4
UCEC	ENOPH1 →	+0.394	+1.879	<.001	<.001	3	4
COAD	TYMS →	+0.848	+3.087	<.001	<.001	3	4
UCEC	CPSF7 →	+0.239	+2.091	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,244 associations by consensus.

GUCA1B by NID2 expression — UCEC

Explore this box plot interactively →