NID2

Across TCGA patient cohorts, NID2 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NID2-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and ATM. Each is linked with NID2 in more than 5 cancer types. Because this analysis shows association rather than direction, both NID2-to-partner and partner-to-NID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NID2-low versus NID2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NID2→partner) and Y-score (partner→NID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ASNS →	+0.479	+2.331	.003	.003	3	6
COAD	Caspase-7-cleavedD198 →	+1.602	+3.338	<.001	.004	3	4
UCEC	ATM →	-0.440	-2.234	<.001	.001	3	4
UCEC	4E-BP1 →	+0.259	+1.904	<.001	.001	3	4
LUAD	p70-S6K →	+0.308	+3.459	.002	.005	2	4
UCEC	GAPDH →	+0.303	+1.906	.038	.014	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

ASNS by NID2 expression — LUSC

Explore this box plot interactively →