NID2

Across TCGA cell cohorts, NID2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,839 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NID2-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Positive regulation of cell-matrix adhesion, and Regulation of mRNA splicing, via spliceosome. Each is linked with NID2 in more than 9 cancer types. Because this analysis shows association rather than direction, both NID2-to-partner and partner-to-NID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by NID2-low versus NID2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NID2→partner) and Y-score (partner→NID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of syncytium formation by plasma membrane fusion →	+0.068	+1.471	.002	.001	3	10
BONE	Positive regulation of cell-matrix adhesion →	+0.160	+3.507	.002	.002	3	9
BLOOD_Leukemia	Regulation of mRNA splicing, via spliceosome →	+0.076	+1.728	<.001	<.001	3	9
BLOOD_Myeloma	Regulation of RNA splicing →	+0.049	+0.676	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.154	+1.702	<.001	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.150	+1.679	<.001	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,839 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by NID2 expression — SKIN

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