NID2

Across TCGA cell cohorts, NID2 mutation is significantly associated with the RNA expression of many other genes, with 677 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NID2-associated genes across cancer lineages are DCK, FAM236A, and TCP10L2. Each is linked with NID2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NID2-to-partner and partner-to-NID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCK grouped by NID2-low versus NID2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NID2→partner) and Y-score (partner→NID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCK →	+0.600	+2.502	.001	.005	3	3
BREAST	FAM236A →	+0.050	+3.781	<.001	.009	3	2
SKIN	TCP10L2 →	+0.048	+3.192	.002	.002	3	2
SKIN	INO80E →	+0.301	+3.299	.006	.004	3	2
LARGE_INTESTINE	GSR →	+0.829	+3.628	.001	<.001	3	2
LARGE_INTESTINE	KCTD9 →	+0.798	+2.502	.002	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 677 associations by consensus.

DCK by NID2 expression — LARGE_INTESTINE

Explore this box plot interactively →