NID1

Across TCGA patient cohorts, NID1 mutation is significantly associated with the RNA expression of many other genes, with 4,501 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NID1-associated genes across cancer lineages are MYO19, LRRC59, and CYP27B1. Each is linked with NID1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NID1-to-partner and partner-to-NID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO19 grouped by NID1-low versus NID1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NID1→partner) and Y-score (partner→NID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO19 →	+0.419	+1.469	<.001	<.001	3	5
UCEC	LRRC59 →	+0.480	+2.528	<.001	<.001	3	4
UCEC	CYP27B1 →	+0.377	+1.656	<.001	<.001	3	4
UCEC	CEP55 →	+0.503	+1.893	.002	<.001	3	4
UCEC	BOLA3 →	+0.316	+2.169	<.001	<.001	3	4
UCEC	PATL1 →	+0.376	+1.949	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,501 associations by consensus.

MYO19 by NID1 expression — UCEC

Explore this box plot interactively →