NID1

Across TCGA patient cohorts, NID1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NID1-associated genes across cancer lineages are VHL, PDCD4, and Caspase-7-cleavedD198. Each is linked with NID1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NID1-to-partner and partner-to-NID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by NID1-low versus NID1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NID1→partner) and Y-score (partner→NID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VHL →	-0.651	-2.459	.009	.017	3	4
UCEC	PDCD4 →	-0.457	-1.513	<.001	.006	3	3
UCEC	Caspase-7-cleavedD198 →	+0.618	+1.958	<.001	<.001	3	3
UCEC	p62 Lck ligand →	+0.361	+2.146	<.001	<.001	3	3
UCEC	C-Raf →	+0.168	+2.415	<.001	.002	3	3
COAD	c-Kit →	-0.583	-1.700	.004	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

VHL by NID1 expression — COAD

Explore this box plot interactively →