NID1

Across TCGA cell cohorts, NID1 mutation is significantly associated with the RNA expression of many other genes, with 592 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NID1-associated genes across cancer lineages are C8orf86, DTWD1, and BBS7. Each is linked with NID1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NID1-to-partner and partner-to-NID1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8orf86 grouped by NID1-low versus NID1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NID1→partner) and Y-score (partner→NID1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C8orf86 →	+0.079	+2.602	.001	.009	3	2
LARGE_INTESTINE	DTWD1 →	+0.625	+2.158	<.001	.004	3	2
LARGE_INTESTINE	BBS7 →	+0.543	+2.523	.002	.003	3	2
LARGE_INTESTINE	LARP1B →	+0.677	+3.087	<.001	.006	3	2
LARGE_INTESTINE	MSGN1 →	+0.051	+2.208	<.001	.002	3	2
LARGE_INTESTINE	EEF1A1 →	+0.450	+2.158	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 592 associations by consensus.

C8orf86 by NID1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →