NICN1

Across TCGA cell cohorts, NICN1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NICN1-associated genes across cancer lineages are ADRA1A and DEFB134. Each is linked with NICN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NICN1-to-partner and partner-to-NICN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADRA1A grouped by NICN1-low versus NICN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NICN1→partner) and Y-score (partner→NICN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADRA1A →	+0.227	+4.705	<.001	.003	3	1
BLOOD_Leukemia	DEFB134 →	+0.017	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ADRA1A by NICN1 expression — BLOOD_Leukemia

Explore this box plot interactively →