NIBAN3

Across TCGA patient cohorts, NIBAN3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIBAN3-associated genes across cancer lineages are ERK2, NF-kB-p65_pS536, and ER-alpha_pS118. Each is linked with NIBAN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIBAN3-to-partner and partner-to-NIBAN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NIBAN3-low versus NIBAN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIBAN3→partner) and Y-score (partner→NIBAN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.181	+2.584	.023	.010	3	2
LUSC	NF-kB-p65_pS536 →	+0.475	+2.816	.025	.036	3	1
UCEC	ER-alpha_pS118 →	+0.307	+3.183	.038	.009	3	1
UCEC	JNK2 →	+0.249	+2.469	.002	.010	3	1
UCEC	p27_pT198 →	+0.111	+3.459	.012	.005	3	1
UCEC	p62 Lck ligand →	+0.472	+3.594	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ERK2 by NIBAN3 expression — UCEC

Explore this box plot interactively →