NIBAN2

Across TCGA patient cohorts, NIBAN2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIBAN2-associated genes across cancer lineages are MEK1, eIF4E, and JNK2. Each is linked with NIBAN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NIBAN2-to-partner and partner-to-NIBAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NIBAN2-low versus NIBAN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIBAN2→partner) and Y-score (partner→NIBAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.326	+2.000	.023	.010	3	2
UCEC	eIF4E →	+0.213	+3.183	.010	.009	3	2
UCEC	JNK2 →	+0.310	+3.348	<.001	.004	3	2
UCEC	Annexin-1 →	+0.543	+1.894	.008	.030	3	2
SKCM	YAP_pS127 →	-0.474	-3.000	.020	.036	1	3
SKCM	CD49b →	+0.428	+3.017	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MEK1 by NIBAN2 expression — UCEC

Explore this box plot interactively →