Across TCGA patient cohorts, NHSL2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHSL2-associated genes across cancer lineages are ASNS, PKC-b-II_pS660, and ARID1A. Each is linked with NHSL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NHSL2-to-partner and partner-to-NHSL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHSL2→partner) and Y-score (partner→NHSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.470	+2.178	.011	.035	3	3
COAD	PKC-b-II_pS660 →	-0.447	-3.313	.007	.010	3	2
COAD	ARID1A →	+0.193	+2.821	.016	.035	3	2
UCEC	A-Raf_pS299 →	-0.078	-1.362	.024	.034	3	2
UCEC	MEK1 →	+0.413	+2.736	<.001	<.001	3	2
UCEC	p21 →	+0.141	+1.295	.011	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

NHSL2 survival (RNA) · tumor vs normal (RNA) · all NHSL2 data types