NHSL1

Across TCGA pan-cancer cohorts, NHSL1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NHSL1 data layer compared with 17 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NHSL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NHSL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and OV are the cancer types where NHSL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	1.000	0.758	.013	21	view →
GBM	DFS	Median	All	0.812	0.625	<.001	18	view →
OV	DFS	Median	All	0.467	0.900	.006	16	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.349	.006	16	view →
HNSC	DFS	Tertile	All	0.991	0.877	.008	8	view →
LUAD	OS	Tertile	II,III,IV	0.326	0.764	.021	8	view →
PDAC	DFS	Tertile	II,III,IV	0.472	0.294	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NHSL1–LSCC (DFS)

Open the LSCC breakdown →