NHSL1

Across TCGA patient cohorts, NHSL1 mutation is significantly associated with the RNA expression of many other genes, with 5,065 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHSL1-associated genes across cancer lineages are IL2RB, GNPNAT1, and ADNP2. Each is linked with NHSL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NHSL1-to-partner and partner-to-NHSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2RB grouped by NHSL1-low versus NHSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHSL1→partner) and Y-score (partner→NHSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL2RB →	+0.893	+1.868	<.001	<.001	3	3
UCEC	GNPNAT1 →	+0.547	+1.809	<.001	.001	3	3
UCEC	ADNP2 →	+0.531	+2.040	<.001	.001	3	3
UCEC	LACTB →	+0.501	+1.680	<.001	<.001	3	3
COAD	NKG7 →	+1.162	+3.013	<.001	<.001	3	3
UCEC	XPNPEP1 →	+0.419	+2.180	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,065 associations by consensus.

IL2RB by NHSL1 expression — UCEC

Explore this box plot interactively →