NHSL1

Across TCGA patient cohorts, NHSL1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHSL1-associated genes across cancer lineages are ATM, p62 Lck ligand, and S6_pS240_S244. Each is linked with NHSL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NHSL1-to-partner and partner-to-NHSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NHSL1-low versus NHSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHSL1→partner) and Y-score (partner→NHSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.430	-1.222	.003	.035	3	3
UCEC	p62 Lck ligand →	+0.424	+2.000	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.262	+1.700	.046	.042	3	2
COAD	beta-Catenin →	-0.980	-3.161	.002	.019	3	2
COAD	E-Cadherin →	-1.076	-3.161	<.001	.019	3	2
UCEC	14-3-3_beta →	-0.093	-2.067	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by NHSL1 expression — UCEC

Explore this box plot interactively →