Across TCGA patient cohorts, NHS mutation is significantly associated with the RNA expression of many other genes, with 5,980 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHS-associated genes across cancer lineages are ZFYVE19, RAB8A, and RBPJ. Each is linked with NHS in more than 3 cancer types. Because this analysis shows association rather than direction, both NHS-to-partner and partner-to-NHS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHS→partner) and Y-score (partner→NHS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZFYVE19 →	+0.327	+1.243	<.001	<.001	3	4
UCEC	RAB8A →	+0.226	+1.358	.002	<.001	3	4
COAD	RBPJ →	+0.370	+3.183	.007	.009	3	4
UCEC	PGAM1 →	+0.637	+1.610	<.001	<.001	3	4
UCEC	ZIC2 →	+1.238	+1.254	<.001	<.001	3	4
COAD	ZIC5 →	+0.890	+2.415	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,980 associations by consensus.

Exploration

NHS survival (RNA) · tumor vs normal (RNA) · all NHS data types