Across TCGA patient cohorts, NHS mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHS-associated genes across cancer lineages are CDK1, INPP4B, and Caspase-7-cleavedD198. Each is linked with NHS in more than 3 cancer types. Because this analysis shows association rather than direction, both NHS-to-partner and partner-to-NHS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHS→partner) and Y-score (partner→NHS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CDK1 →	+0.132	+2.179	.033	.035	3	3
COAD	INPP4B →	-0.661	-3.584	<.001	.002	2	4
COAD	Caspase-7-cleavedD198 →	+1.436	+2.815	<.001	.001	3	3
LUSC	YB-1_pS102 →	+0.188	+3.386	.007	.004	3	2
UCEC	JNK2 →	+0.240	+2.000	<.001	<.001	3	2
COAD	eIF4E →	+0.194	+2.182	.005	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Exploration

NHS survival (RNA) · tumor vs normal (RNA) · all NHS data types