Across TCGA cell cohorts, NHS mutation is significantly associated with the RNA expression of many other genes, with 355 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NHS-associated genes across cancer lineages are KCNA6, B4GALNT2, and CXorf51A. Each is linked with NHS in more than 1 cancer types. Because this analysis shows association rather than direction, both NHS-to-partner and partner-to-NHS results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHS→partner) and Y-score (partner→NHS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KCNA6 →	+0.004	+3.378	<.001	.006	3	2
BLOOD_Leukemia	B4GALNT2 →	+0.034	+5.066	<.001	.001	3	2
LUNG_NSCLC_LUAD	CXorf51A →	+0.076	+4.887	<.001	.009	3	2
SOFT_TISSUE	AVP →	+0.078	+4.392	<.001	.004	3	1
SOFT_TISSUE	TENT5D →	+0.051	+3.999	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.052	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 355 associations by consensus.

Exploration

NHS survival (RNA) · tumor vs normal (RNA) · all NHS data types