NHLRC4

Across TCGA pan-cancer cohorts, NHLRC4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NHLRC4 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher NHLRC4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NHLRC4 expression acts as an unfavorable survival marker.

SKCM, UCEC, and LIHC are the cancer types where NHLRC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.212	0.694	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NHLRC4–SKCM (DFS)

Open the SKCM breakdown →