Across TCGA pan-cancer cohorts, NHLRC3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NHLRC3 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NHLRC3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NHLRC3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where NHLRC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.540	0.749	.008	26	view →
CCRCC	OS	Tertile	All	0.983	0.822	.009	19	view →
LUAD	DFS	Tertile	All	1.000	0.558	.006	16	view →
LSCC	DFS	Median	All	0.883	0.978	.009	9	view →
UCEC	DFS	Tertile	All	0.978	0.795	.019	8	view →
PDAC	OS	Median	All	0.942	0.719	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: NHLRC3 tumor-vs-normal RNA expression · all NHLRC3 data types