NHLRC3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NHLRC3 mutation is significantly associated with the RNA expression of many other genes, with 1,073 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHLRC3-associated genes across cancer lineages are ADNP2, C1QBP, and SRSF4. Each is linked with NHLRC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLRC3-to-partner and partner-to-NHLRC3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLRC3→partner) and Y-score (partner→NHLRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECADNP2 →+0.490+2.847.007.00132
UCECC1QBP →+0.570+2.628.001.00532
UCECSRSF4 →+0.346+1.963.005.00832
UCECGOT1 →+0.444+2.727.001<.00132
UCECEMC6 →+0.747+3.807<.001<.00132
UCECUBR7 →+0.535+2.721<.001.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,073 associations by consensus.

Exploration