NHLRC2

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NHLRC2 mutation is significantly associated with the RNA expression of many other genes, with 1,142 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHLRC2-associated genes across cancer lineages are CD3D, LAG3, and NDUFA5P5. Each is linked with NHLRC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLRC2-to-partner and partner-to-NHLRC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLRC2→partner) and Y-score (partner→NHLRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCD3D →+0.950+2.923.001<.00132
UCECLAG3 →+0.978+2.194<.001.00132
COADNDUFA5P5 →+0.082+4.332.006.00632
LUADMIR3663HG →+0.047+4.631<.001.00832
CESCRNU6-1214P →+0.355+5.306<.001.00632
CESCDNMT3AP1 →+0.030+5.418<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,142 associations by consensus.

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