Across TCGA patient cohorts, NHLRC2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHLRC2-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and IGFBP2. Each is linked with NHLRC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLRC2-to-partner and partner-to-NHLRC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLRC2→partner) and Y-score (partner→NHLRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.293	+2.584	.003	.010	3	2
UCEC	EGFR_pY1068 →	-0.220	-1.874	.019	.049	3	1
UCEC	IGFBP2 →	-0.849	-2.169	<.001	.003	3	1
UCEC	JNK2 →	+0.246	+2.169	<.001	.003	3	1
UCEC	Ku80 →	+0.242	+1.778	.006	.008	3	1
UCEC	MAPK_pT202_Y204 →	-0.384	-2.000	.029	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

NHLRC2 survival (RNA) · tumor vs normal (RNA) · all NHLRC2 data types