Across TCGA patient cohorts, NHLRC1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHLRC1-associated genes across cancer lineages are GATA6, ACVRL1, and Notch1. Each is linked with NHLRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLRC1-to-partner and partner-to-NHLRC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLRC1→partner) and Y-score (partner→NHLRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.186	-3.321	.016	.010	3	1
UCEC	ACVRL1 →	-0.195	-2.980	.004	.036	3	1
UCEC	Notch1 →	+0.228	+2.820	.001	.035	3	1
UCEC	N-Ras →	-0.124	-3.446	.037	.005	3	1
UCEC	Annexin-1 →	+0.829	+3.019	.001	.019	3	1
UCEC	RBM15 →	+0.336	+3.169	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

NHLRC1 survival (RNA) · tumor vs normal (RNA) · all NHLRC1 data types