Across TCGA cell cohorts, NHLRC1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NHLRC1-associated genes across cancer lineages are AVP, C1QBP, and ELOVL3. Each is linked with NHLRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLRC1-to-partner and partner-to-NHLRC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLRC1→partner) and Y-score (partner→NHLRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.044	+3.310	<.001	<.001	3	1
LARGE_INTESTINE	C1QBP →	+0.735	+3.131	.003	.008	3	1
LARGE_INTESTINE	ELOVL3 →	+1.252	+3.064	<.001	.009	3	1
LARGE_INTESTINE	PRDM7 →	+0.142	+3.539	.002	.004	3	1
LARGE_INTESTINE	NR2E3 →	+0.408	+3.330	<.001	.004	3	1
LARGE_INTESTINE	LBHD2 →	+0.087	+3.009	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

NHLRC1 survival (RNA) · tumor vs normal (RNA) · all NHLRC1 data types