Across TCGA cell cohorts, NHLRC1 mutation is significantly associated with the mutation status of many other genes, with 2,298 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NHLRC1-associated genes across cancer lineages are OR2M2, CD3E, and ZBTB8B. Each is linked with NHLRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLRC1-to-partner and partner-to-NHLRC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLRC1→partner) and Y-score (partner→NHLRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M2 →	+3.544	+3.321	<.001	<.001	1	2
LARGE_INTESTINE	CD3E →	+3.807	+3.137	.001	.001	1	2
LARGE_INTESTINE	ZBTB8B →	+2.807	+2.954	.001	.001	1	2
LARGE_INTESTINE	ZCCHC8 →	+3.222	+2.893	.003	.003	1	2
LARGE_INTESTINE	PHLPP2 →	+2.321	+2.643	.004	.004	1	2
LARGE_INTESTINE	CAPG →	+3.807	+3.137	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,298 associations by consensus.

Exploration

NHLRC1 survival (RNA) · tumor vs normal (RNA) · all NHLRC1 data types