NHLH2

Across TCGA patient cohorts, NHLH2 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHLH2-associated genes across cancer lineages are Monocytes, Eosinophils, and Preadipocytes. Each is linked with NHLH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLH2-to-partner and partner-to-NHLH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by NHLH2-low versus NHLH2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLH2→partner) and Y-score (partner→NHLH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	Monocytes →	+0.010	+5.305	.044	.048	3	2
LUSC	Eosinophils →	+0.033	+3.173	.023	.049	3	1
COAD	Preadipocytes →	+0.065	+3.169	<.001	.015	3	1
UCEC	pDC →	+0.057	+3.032	.020	.018	3	1
UCEC	Th2 cells →	+0.192	+2.321	.033	.036	3	1
UCEC	Endothelial cells →	-0.052	-3.416	.007	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Monocytes by NHLH2 expression — LIHC

Explore this box plot interactively →