NHLH2

Across TCGA cell cohorts, NHLH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 624 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NHLH2-associated GO terms across cancer lineages are Cytoplasmic translation, Regulation of macrophage fusion, and Positive regulation of macrophage fusion. Each is linked with NHLH2 in more than 4 cancer types. Because this analysis shows association rather than direction, both NHLH2-to-partner and partner-to-NHLH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translation grouped by NHLH2-low versus NHLH2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLH2→partner) and Y-score (partner→NHLH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytoplasmic translation →	+0.058	+1.484	<.001	.003	3	5
BLOOD_Myeloma	Regulation of macrophage fusion →	-0.222	-0.005	.004	.007	3	4
BLOOD_Myeloma	Positive regulation of macrophage fusion →	-0.222	-0.005	.004	.007	3	4
LUNG_SCLC	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.072	+2.306	.004	.003	3	4
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.050	+1.568	.004	.008	3	4
LUNG_SCLC	Microtubule cytoskeleton organization involved in establishment of planar polarity →	+0.250	+2.346	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 624 associations by consensus.

Cytoplasmic translation by NHLH2 expression — LUNG_SCLC

Explore this box plot interactively →