NHLH1

Across TCGA patient cohorts, NHLH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,104 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible NHLH1-associated GO terms across cancer lineages are Protein K11-linked ubiquitination, Positive regulation of DNA metabolic process, and Cytoskeleton-dependent cytokinesis. Each is linked with NHLH1 in more than 26 cancer types. Because this analysis shows association rather than direction, both NHLH1-to-partner and partner-to-NHLH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein K11-linked ubiquitination grouped by NHLH1-low versus NHLH1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLH1→partner) and Y-score (partner→NHLH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein K11-linked ubiquitination →	+0.052	+0.249	.001	<.001	2	27
STAD	Positive regulation of DNA metabolic process →	+0.050	+0.151	<.001	<.001	3	26
SCLC	Cytoskeleton-dependent cytokinesis →	+0.089	+2.513	<.001	<.001	3	26
SCLC	Protein localization to chromosome →	+0.139	+2.567	<.001	<.001	2	27
ESCA	Regulation of proteolysis involved in protein catabolic process →	+0.058	+0.296	.001	<.001	3	26
SCLC	Protein localization to cytoskeleton →	+0.094	+2.060	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,104 associations by consensus.

Protein K11-linked ubiquitination by NHLH1 expression — ESCA

Explore this box plot interactively →