NHLH1

Across TCGA patient cohorts, NHLH1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHLH1-associated genes across cancer lineages are LKB1, AR, and 4E-BP1_pT70. Each is linked with NHLH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHLH1-to-partner and partner-to-NHLH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LKB1 grouped by NHLH1-low versus NHLH1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHLH1→partner) and Y-score (partner→NHLH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LKB1 →	+0.107	+3.008	.036	.019	3	1
COAD	AR →	+0.316	+3.008	<.001	.019	3	1
COAD	4E-BP1_pT70 →	+0.130	+3.008	.037	.019	3	1
COAD	Collagen-VI →	+0.557	+3.008	.013	.019	3	1
COAD	Cyclin-D1 →	+0.141	+3.008	.037	.019	3	1
UCEC	A-Raf_pS299 →	-0.121	-3.321	.029	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

LKB1 by NHLH1 expression — COAD

Explore this box plot interactively →