Across TCGA pan-cancer cohorts, NHEJ1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NHEJ1 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NHEJ1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NHEJ1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where NHEJ1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.893	0.543	.007	33	view →
HNSC	OS	Median	All	1.000	0.449	.023	28	view →
LSCC	OS	Quartile	All	0.762	0.965	.007	8	view →
LUAD	DFS	Median	All	0.749	0.479	.005	4	view →
PDAC	DFS	Median	III,IV	0.852	0.467	.018	2	view →
GBM	DFS	Quartile	All	0.295	0.443	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: NHEJ1 tumor-vs-normal RNA expression · all NHEJ1 data types