Across TCGA patient cohorts, NHEJ1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,412 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible NHEJ1-associated genes across cancer lineages are ATP8A1, SPOCD1, and CERCAM. Each is linked with NHEJ1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NHEJ1-to-partner and partner-to-NHEJ1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHEJ1→partner) and Y-score (partner→NHEJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATP8A1 →	+0.962	+0.260	<.001	<.001	3	5
GBM	SPOCD1 →	-1.101	-0.322	.001	<.001	3	4
BRCA	CERCAM →	-0.719	-0.302	<.001	<.001	3	4
BRCA	EPS8L1 →	-0.815	-0.255	.003	.001	3	4
UCEC	HILPDA →	-0.966	-0.264	.001	<.001	3	4
CCRCC	CKAP4 →	-0.759	-0.303	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,412 associations by consensus.

Exploration

NHEJ1 survival (RNA) · tumor vs normal (RNA) · all NHEJ1 data types