Across TCGA patient cohorts, NHEJ1 mutation is significantly associated with the RNA expression of many other genes, with 682 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHEJ1-associated genes across cancer lineages are MIR4510, RNU6-1252P, and RNA5SP517. Each is linked with NHEJ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHEJ1-to-partner and partner-to-NHEJ1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHEJ1→partner) and Y-score (partner→NHEJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4510 →	+0.474	+7.485	<.001	<.001	3	2
BLCA	RNU6-1252P →	+0.263	+7.640	<.001	.009	3	1
BLCA	RNA5SP517 →	+0.238	+7.640	<.001	.009	3	1
UCEC	GLB1L2 →	-1.071	-3.700	<.001	.001	3	1
UCEC	SLC7A11 →	+0.913	+3.700	.005	.001	3	1
UCEC	CENPH →	+0.701	+2.595	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 682 associations by consensus.

Exploration

NHEJ1 survival (RNA) · tumor vs normal (RNA) · all NHEJ1 data types